Dietary restriction exacerbates Alzheimer’s features in mice

Effects of hyperoxia in alzheimers transgenic mice

Indy knockdown in mice mimics elements of dietary restriction

A new mouse knock-out of the Indy gene sheds light on the mechanisms by which a reduction in Indy may lead to a healthier life. Mutations in the Indy gene (for I’m not dead yet) were first described in flies where they dramatically extend life span without a loss in fertility, physical activity, flight velocity or metabolic rate [1, 2]. The Indy gene codes for a high-affinity dicarboxylate/citr...

Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis

BACKGROUND Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal cord. OBJECTIVE We analyzed the spinal cords of G93A mice following dietary D3 restriction at 2.5% the adequate...

Papaver Rhoeas L. Hydroalcoholic Extract Exacerbates Forced Swimming Test-Induced Depression in Mice

Introduction: Depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. In the present study, the effect of water-alcoholic extract of Papaver rhoeas L. on forced swimming test (FST) in Swiss-Webster mice were examined. Methods: We used Swiss-Webster mice (20-25 g) to execute FST on them. The plant extract (1, 10, 30, a...

Fish oil exacerbates colitis in SMAD3 mice.

There are seemingly disparate results from epidemiologic studies regarding associations between fish or marine n-3 polyunsaturated fatty acids (PUFA) intake and colorectal cancer risk. A recent report by Woodworth et al. (1) provides clarity for why a potential etiologic factor, such as fish intake, appears protective for colorectal cancer in some populations, but risk enhancing in other popula...